Cystic fibrosis diagnosed after two months of age leads to worse outcomes and requires more therapy Newborn screening for cystic fibrosis remains controversial because improved pulmonary function has not been established.
Cystic fibrosis diagnosed after two months of age leads to worse outcomes and requires more therapy
Newborn screening for cystic fibrosis remains controversial because improved pulmonary function has not been established.
Two groups of children aged one to ten were stratified into 'newborn-screened, early-clinically diagnosed', or 'late-clinically diagnosed' cohorts. Newborn screening was associated with improved growth, reduced morbidity and reduced therapy, yet generated equivalent pulmonary outcome compared with late clinical diagnosis, suggesting that newborn screening may slow cystic fibrosis lung disease progression.
Sims, E et al. Pediatrics 119(1): 19-28, Jan 2007. Abstract: http://pediatrics.aappublications.org
