The Immigration and Nationality Directorate took the decision to close the Sunbeam Nursery, which is managed by Bright Horizons Family Solutions, without consultation.
Six-hundred parents have signed a petition organised by the Public and Commercial Services Union, which they intend to present to immigration minister Liam Byrne.
Many are concerned that the costs of making new childcare arrangements could force them to give up their jobs.
The Home Office has not said what alternative childcare provision, if any, would be offered.
The lease on Quest House, where the nursery is situated, does not run out until 2009. But union spokesman Ragesh Khakhria said he had been told that the nursery would be closed by the end of December.
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